“Our initial goal was to identify new pathways that contribute to heart disease. Even when treating cardiovascular disease risk factors to goal (e.g. cholesterol, blood pressure, diabetes, etc.), the majority of events (heart attack, stroke, death) continue to occur, or at best, we reduce the event rate by 50%. This means there are other pathways we are not addressing,” Dr. Hazen explained.Dr. Hazen said he and his team were looking for compounds in the blood that might contribute to the future development of heart attack, stroke, or death independent of traditional risk factors.